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3CL protease inhibition (Holidays Gift)
🕑 Added 2024-12-24 22:13:31 +0000 UTCThe 3CL protease, also referred to as the main protease (M^pro) in coronaviruses, is a pivotal enzyme for the viral life cycle.
In SARS-CoV-2 and other coronaviruses, this protease is essential to the replication process because it cleaves the large polyprotein chain encoded by the viral genome into multiple functional components. Essentially, once the virus enters a human cell, it begins translating its RNA into a few gigantic polyproteins, which need to be cut at specific locations to release smaller proteins like the RNA-dependent RNA polymerase, helicase, and other factors responsible for building new viral copies. Without precise cleaving at those positions, the virus cannot assemble the machinery it needs to replicate, and thus the infection cycle grinds to a halt.
If the 3CL protease is blocked, it can’t generate the smaller functional fragments from the viral polyprotein, leaving the virus incapable of proper replication.
From a therapeutic vantage, blocking the protease at an early stage of infection can dramatically cut down on the amount of virus produced in an infected cell, which in turn reduces the viral load throughout the body. If given early enough- particularly in individuals at high risk of complications - this can translate into fewer hospitalizations and milder disease outcomes, a concept that gained attention during the COVID-19 pandemic. In that period, research teams rushed to identify novel 3CL inhibitors or repurpose existing compounds that might have partial activity against similar proteases. Some designs borrowed from older experiences with protease inhibitors in HIV and hepatitis C, though the coronavirus 3CL protease has unique structural features that set it apart from its counterparts in those viruses.
The strength of targeting 3CL protease lies in how conserved it tends to be across variants. Unlike the spike protein, which mutates constantly to avoid neutralizing antibodies, the protease’s active site can’t undergo too much tinkering without crippling the virus’s ability to replicate. That means inhibitors often remain broadly active even when new variants emerge, making 3CL inhibition a more stable approach - at least so far - than therapies that rely on neutralizing specific spike variants.
Because coronaviruses rely so heavily on 3CL protease for repeated cleavage events, even partial inhibition can significantly reduce the viral output.
Many experts anticipate that 3CL protease inhibitors will remain a cornerstone of antiviral therapy, both for SARS-CoV-2 and for other related coronaviruses that may emerge in the future.
Happy holidays everyone!
Comments
Elyas
Where's this man? I cant find it on patreon
Psychic University
Very nice! Thanks for sharing.
CosmicFlow
I got Covid 3 times this season. The third time I found out about this. Much to my surprise, Paxlovid uses the same mechanism to target 3CL. Looped for hours and it brought my symptoms down quickly.
Dan Theman
I cant find the helicobacter field, sure you have published it ?
Dan Theman
Irritable bowl field then :)
Psychic University
This one is created already, just testing on more people.
Psychic University
@Dan I'm not sure if I get your question
Sam Behrens
Hey PU I am happy to volunteer my time if you’d like some help to get these things off the ground 🙂
YWill
You have to ask SIGH energy and not PU
YWill
Thanks
Dan
What about if I buy astrological Charisma buff, is it programmed/possible for that to become permanent ?
Psychic University
I have no idea honestly, it depends on how it was programmed
Dan
Hi, I am a new patron I have a question. I have a custom field from Sigh Energy based on 28 Numerology birthday & Leo Ascendant and Midheaven Placements. I am naturally an Aries (April 17th 2003) double 17/17 life path, and I receive results when I use the Leo & 28 energy file. My question is can this become permanent? If everything is energy, and astrology and numerology are the energies given to you at birth, can I override and make permanent of these Leo and 28 energies in a PERMANENT fashion? How can this be achieved / if my birthday is still officially April 17th
Dan Theman
Maybe one on helicobacter pylori too, thats another nasty one.
Psychic University
I need to finish the website first.
Psychic University
No, not at the moment.
Psychic University
Studying it for a while, it will eventually come out.
Psychic University
Use the end of viruses in this case. I wish you a good recovery.
Psychic University
Tomorrow. Took my time with some stuff and couldn't release it in time for Christmas.
Powren Man
He said yes, we just don't know when
robie
is there gonna be a new year’s sale?
Manni Gill
Suffering from some disgusting viral thats been going around in UK. You think this would help? It literally feels worser than covid. So many people have it too. 🤔😔
Dan Theman
Could you look into making a probiotic field and a cure histamine intolerance field ? Thank you for all the other fields, just subscribed and fan already.
Hanna
Thank you! So beautiful music 💚
RedWolf
Hey PU, do you have anything for overactivity/muscle spasms in the pelvis/rectal region, besides the Reverse Negative Effects from Sitting too much field? Thank you!
Joanne
PU said he might do it next year.
J A
Man, I think I speak for many of us when I say this. You need to make a forum or a discord, your work is spectacular! The testimonials would fly off the shelf :D
Andee
That would be amazing to have stronger help with HIV/Herpes , flu etc !!
Psychic University
It lingers in the body for years (probably forever), so yes, it should be used by everyone
Psychic University
Yes, for sure.
Psychic University
not on my plans
Bob
Thank you!
Singrid Irwen
Also - can this/should it be used for prevention, is one is not sick?
Singrid Irwen
Wow, revolutionary ! Someday perhaps a prevention tool (or treatment) for things like HIV/Herpes, flu and other nasty viruses (maybe unknown ones?)
zea
Wow, this seems big, Thank you!
Togarashi
Thank you! 🙏
Barry Saey
Thanks!
Yamil E Adorno
Bro do you plan to do ah field alternative to the manly man field where all males hormone get optimized with androgens in an genetic and RNA levels ?
Manni Gill
Thanks bro
