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rs12778366 C;C (SIRT1 Gene)
🕑 Added 2024-12-02 18:00:27 +0000 UTCThe C;C genotype of rs12778366 in the SIRT1 gene is associated with significant improvements in long-term survival and glucose metabolism.
SIRT1 (Sirtuin 1) is a member of the sirtuin family of proteins, which are NAD+-dependent deacetylases. SIRT1 acts as a "metabolic master regulator," influencing numerous physiological processes that are central to aging and metabolic health. Overexpression of SIRT1 has been shown to enhance insulin sensitivity, radipogenesis (fat storage), and improve energy metabolism.
SIRT1 regulates how the body responds to energy scarcity by activating pathways that promote energy conservation and utilization of stored reserves. SIRT1 also modulates inflammation and oxidative stress, both of which are major contributors to aging and metabolic diseases.
In terms of glucose metabolism, carriers of the C allele, particularly those with the C;C genotype, showed improved glucose tolerance as evidenced by the oral glucose tolerance test (OGTT). These individuals had blood glucose levels that were 0.34 mmol/L lower than those with the wild-type genotype. The effect was even more significant in overweight or obese individuals, where glucose levels were reduced by 0.60 mmol/L. This suggests a strong link between the C allele and better regulation of glucose metabolism, which could lower the risk of insulin resistance and type 2 diabetes.
The benefits of the C allele extend across genders, smoking habits, and age groups, making it a robust genetic factor for long-term health.
The C allele of rs12778366 appears to enhance some of the beneficial activities of SIRT1, particularly in metabolic and inflammatory contexts.
This field will install this snp in you. I found a way to do it in a safe and tailored way, so you shouldn't worry about hidden risks. The effect should be permanent.
2-3 times a day is a safe amount.
https://pmc.ncbi.nlm.nih.gov/articles/PMC3591365/
Comments
Minh Chinh Le
Having the C;C genotype of rs12778366 in the SIRT1 gene while boosting NAMPT (Nicotinamide Phosphoribosyltransferase) and NADH (Nicotinamide Adenine Dinucleotide Hydride) could create a powerful synergy for enhancing cellular health, metabolism, and longevity. Here's how these components interact and the potential benefits of combining them: Key Components and Their Roles C;C Genotype of rs12778366 (SIRT1): The C;C genotype is associated with higher SIRT1 expression or activity. SIRT1 is a NAD+-dependent deacetylase that regulates cellular processes like aging, metabolism, stress resistance, and inflammation. NAMPT: NAMPT is the rate-limiting enzyme in the NAD+ salvage pathway, which converts nicotinamide (a form of vitamin B3) into NAD+. Higher NAMPT activity increases cellular NAD+ levels, which are essential for SIRT1 function. NADH: NADH is the reduced form of NAD+, involved in energy production (ATP synthesis) and redox reactions. NADH can be converted back into NAD+, further supporting SIRT1 activity. Synergistic Effects of Combining C;C Genotype, NAMPT, and NADH 1. Enhanced SIRT1 Activation The C;C genotype already promotes higher SIRT1 activity. Boosting NAMPT increases NAD+ levels, which is the primary cofactor required for SIRT1 function. NADH contributes to the NAD+ pool, ensuring a steady supply of this critical molecule. Together, these factors create an optimal environment for maximizing SIRT1 activity, leading to improved cellular repair, metabolism, and stress resistance. 2. Improved Cellular Energy and Mitochondrial Function NADH is directly involved in the electron transport chain, boosting ATP production and mitochondrial efficiency. SIRT1 enhances mitochondrial biogenesis and function, further improving energy metabolism. This combination can reduce fatigue, enhance physical performance, and support overall vitality. 3. Anti-Aging and Longevity SIRT1 is a key regulator of aging, promoting DNA repair, reducing oxidative stress, and enhancing cellular survival. NAD+ (boosted by NAMPT) is essential for SIRT1's anti-aging effects. Together, they can slow down age-related decline and promote longevity. 4. Metabolic Health SIRT1 improves insulin sensitivity and glucose metabolism. NAD+ and NADH support metabolic pathways, including glycolysis and the tricarboxylic acid (TCA) cycle. This combination can help prevent or manage metabolic disorders like type 2 diabetes and obesity. 5. Reduced Inflammation and Oxidative Stress SIRT1 has anti-inflammatory effects by modulating NF-κB signaling. NAD+ supports the activity of other sirtuins and PARPs (poly-ADP-ribose polymerases), which are involved in DNA repair and stress resistance. Together, they can reduce chronic inflammation and oxidative damage, protecting against diseases like cardiovascular disease and neurodegenerative disorders. 6. Neuroprotection SIRT1 protects neurons from oxidative stress and inflammation, which are key factors in neurodegenerative diseases. NAD+ supports brain energy metabolism and neuronal function. This combination may help prevent or slow the progression of conditions like Alzheimer's and Parkinson's disease.
Minh Chinh Le
This one + NAMPT + NADH will get the most out of these fields' effects.
Psychic University
nope
Punna
Thank you! Will Gene Therapy disrupt this install?
Psychic University
The gene in () idea is very good actually, thank you for the suggestion. I will soon be creating a collection for them as well. So it will be easier to find.
GoodBoy33
Thanks to you and captain, I believe I can live to be 100 years old.
Nils
Could you make the file name more descriptive? I guess it could be hard to find this field in your collection. Maybe something like "C;C genotype of rs12778366 in the SIRT1 gene" (taken from the description). Then you'd have a good chance finding it when searching for "gene" or "sirt".
Akasha777
"This field will install this snp in you. I found a way to do it in a safe and tailored way, so you shouldn't worry about hidden risks. The effect should be permanent." - a sign of amazing things to come. May you keep rising, and rising, and rising. ✨️
Barry Saey
Bro you’re always in alignment with my needs at the time. Thank you!
WP
Thank you PU! I sent you a message on here about some downloads I can't access anymore when you get a chance
Psychic University
I mixed up the text as well. Seriously, these names are confusing and you start mixing things up. But the file is with the correct programming, naturally. Always was. Just had to upload the file again with the correct name.
Psychic University
Forgot to make it clear, but yeah, it's permanent. On the first week you already should have it well integrated. But it varies, field work is something almost random in terms of results.
Batuhan Y
Can this be permanent over time?
Psychic University
It will be, I even uploaded the wrong file because their names are very similar and I put the image on the wrong file haha. It's fixed now.
Batuhan Y
Omg please make it a series..
