Dr. Jack Kruse
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DECENTRALIZED MEDICINE #14: The exterior integument process’ governs the internal state
🕑 Added 2024-09-21 11:51:08 +0000 UTCI've received a ton of DMs and emails about my discussion with Dr. Alexis Cowan on our second podcast on T cells and autoimmunity, so I decided to answer them here.
How do I know that the external process on the integument controls the biochemistry process on the interior? Do you know that supplementation of Vitamin D does not work the same in those with heavily melanated exteriors compared to those with Fitzpatrick one and two skin?
Do you understand the implications?
According to the article above, "Doctors frequently prescribe supplemental vitamin D," Freedman said. "However, we do not know all its effects and how they may differ between the races. The bottom line is that racial differences in calcium handling are seen, and black and white patients have differing risks for bone and heart disease. We should more clearly determine the effects of supplementing vitamin D in black patients with low levels based on existing criteria. We should not assume that the effects of supplementation will be the same between the races." Again, this is not a racial story; it is a story of the biophysics of melanin and how POMC is only translated by UV light frequencies.
ARE THERE ANY OTHER LINES OF EVOLUTIONARY EVIDENCE THAT THESE THINGS ARE LINKED TO OUR INTEGUMENT?
YES THERE IS IN DAIRY TOLERANCE. This is food loaded with calcium. HYPERLINK
This explains this fact: 80 percent of all African Americans and Native Americans are lactose intolerant. They have more melanin in their integument. Over 90 percent of Asian Americans are lactose intolerant, and it is least common among Americans with a Northern European heritage who have Fitzpatrick one or two skin.
This important distinction must be made in El Salvador, where 95% of the population has melanated skin. This implies that supplemental Vitamin D is not a wise choice for them.
Brown & Black races generally have lower vitamin D levels than whites, partly because their darker skin pigmentation limits the amount of the vitamin produced by sunlight. This is protective in environments where melanated skin is optimized.
IMPLICATIONS OF THE SURFACE BIOPHYSICS?
Despite these lower vitamin D levels and dietary calcium ingestion, browns & blacks naturally experience lower rates of osteoporosis and have far less calcium in their arteries based on published studies. Studies further reveal that brown/black patients with diabetes have half the rate of heart attack as whites. This shows us that melanated skin may be a protective effect from blue light and nnEMF exposure. This also shows us that lower levels of calcified atherosclerotic plaque in brown & blacks are associated with a lower risk of heart disease. The irony is in the stroke and heart attack belt in the US, browns & blacks in the general community have higher rates of heart attack than whites. This implies that their circadian mismatch to a higher latitude likely explains their decreased longevity. This is why my pinned tweet exists. Vitamin D is not the best end-all story in longevity. It can be used as a good proxy for whites, but we should not assume the same for browns & blacks. Browns & blacks clearly get disease faster and more severe than whites at the same latitude. This again points to a lack of proper sunlight being the main culprit in disease creation.
Humans have CYP11A1-derived secosteroids in their epidermis and serum. What does it do?
CYP11A1 drives a novel magnetochemical pathway in the vitamin D3 (D3) and 7-dehydrocholesterol (7DHC) metabolic pathways in humans. CYP11A1 initiates it. The CYP11A1 SNP has been previously characterized in vitro papers. It has also been proven to occur in vivo in humans. The researchers in those papers analyzed samples of human serum, epidermis, and pig adrenals for the presence of intermediates and products of these pathways. What did they find, and why did it sway me that the electric state of our membranes is giving direct feedback control to metabolism below inside of cells?
In the paper linked below, the epidermal, serum and adrenal samples showed the presence of D3 hydroxy-derivatives corresponding to 20(OH)D3, 22(OH)D3, 25(OH)D3, 1,25(OH)2D3, 20,22(OH)2D3, 20,23(OH)2D3, 20,24(OH)2D3, 20,25(OH)2D3, 20,26(OH)2D3, 1,20,23(OH)3D3 and 17,20,23(OH)3D3, plus 1,20(OH)2D3 which was detectable only in the epidermis.
Serum concentrations of 20(OH)D3 and 22(OH)D3 were only 30- and 15-fold lower than 25(OH)D3, respectively, and at levels above those required for biological activity as measured in vitro.
They also detected 1,20,24(OH)3D3, 1,20,25(OH)3D3 and 1,20,26(OH)3D3 in the adrenals. Products of CYP11A1 action on 7DHC, namely 22(OH)7DHC, 20,22(OH)27DHC, and 7-dehydropregnenolone, were also detected in serum, epidermis, and the adrenal gland. Thus, research has shown that humans have novel CYP11A1-derived secosteroids in the skin, serum, and adrenal gland. This SNP likely has much to do with why we deleted the Vitamin C gene in the human genome. Moreover, as I told Dr. Cowan, based on the concentrations found in the papers, their biological activity suggests that they act as hormones in vivo.
T cells undergo positive and negative selection in the thymus through T cell receptor (TCR) recognition of peptides presented on major histocompatibility (MHC) proteins. Although the genes encoding MHC proteins are among the most polymorphic, most vertebrates express relatively few MHC alleles individually. Genes only act to alter metabolic flux, as the picture above shows. How the number of MHC alleles expressed affects thymic selection and the TCR repertoire on an individual level remains unclear to centralized science. Decentralized science has a different viewpoint. I think sunlight on the skin changes our microbiome and sculpts it to create free radicals and light changes from the microbiomes, creating a variability response in our CD4 and CD 8 cells.
SUMMARY
This is my current hypothesis. I believe sunlight creates T-cell variability in our skin and gut surfaces, as I mentioned below with Dr. Cowan. I think sunlight stimulates MHC heterozygosity, which improves immunity by reducing receptor variability in T cells. MHC heterozygosity limits T cell receptor variability in CD4 T cells. T cells are essential for recognizing infectious agents through their receptors (TCRs), which engage peptides derived from invaders or auto-antigens bound to major histocompatibility complex proteins (MHC). While much research has focused on MHC peptide specificity, the impact of MHC on the expressed TCR repertoire, especially in MHC heterozygotes, has not been well studied in centralized science. Understanding this decentralized link in medicine should guide personalized autoimmune monitoring and better predictive responses to various new treatments. Sunlight exposure to 380nm and 1280 nm light is mandatory in any autoimmune reversal. It should be from sunlight and not any manmade light.
The blog's parting thought is about pharmaceuticals for autoimmune conditions: The human condition does not require that you take drugs that pharmaceutical companies sell. You do not have a pharmaceutical deficiency or a "chemical imbalance." BigHarma sells these ideas to keep you believing their BS. Pharmaceutical companies demand that you consume what they sell. You can live strong and healthy without them. Learn how and do it. Decentralized medicine and healthcare teach these techniques.
Time is your most valuable asset in life and links to your choices in health span and how you use your monetary energy. Why doesn't the "food guru" get this concept? They spend too much time under ALAN while in a gym reading flawed nutrition data and not enough time reading about the physics of organisms. The erasure of information drives entropy in cells, and this process increases over time. This is a consequence of having a ratio in our universe of 1 billion light photons to every atom. This is why LIGHT> food. All molecular clocks that control circadian biology are flow meters for this entropy measurement. This should tell the ripe mind that circadian biology's light and dark cycles are the key to the biological ENIGMA CODE of all modern diseases, especially autoimmune conditions.
Comments
Dr. Jack Kruse
What would happen if you gave yourself permission to do something you’ve never done before? There’s only one way to find out, isn't there? If you want a new outcome in your life you must begin by doing something you've never done before beginning right now. Get in the sun and turn off the lights at night to protect the regenerative currents in you. Follow your own passion—not your parents’, not your friends or mentors' — just tap your own instincts. There is no passion to be found playing small—in settling for a life that is less than the one you are capable of living. Learn why light is the most dangerous drug out there. It is not food. It is a story about light 100% of the time. https://www.instagram.com/p/DBr1p-ShjFG/
madonna fabian
I’m a hospitalist and more often work at nights, bombard by blue light, might explain my infertility, thanks for the education. I will start getting sunrise, mid sun and sunset.
Shaine Schroeder
^^^ Currently listening to this episode and loving it, considering I’m based in South Dakota. Thanks again Jack! 🤜🤛
Dr. Jack Kruse
Getting more sunlight in Alaska is tough. I do not think it likely and I think listening to the High Latitude podcast I did with Owen Sheasby is your best option. https://www.youtube.com/watch?v=-VFTXZrbyNA
Rebekah Mayfield
I just moved to Alaska and I’m trying to figure out how to more light. I’m also an Esthetician and have preached to my clients to always wear sunscreen and stay out of tanning beds. I am now learning so much through your channel. What alternative do we have? Tanning beds? Incandescent bulbs? I don’t know the indifference in UVA UVB and UVC. Any guidance would be so greatly appreciated. I want to teach my clients the truth!
Dr. Jack Kruse
How about you read the blog on coffee here on Patreon. You are a Patron and it is included!
Al
Dr kruse, I’ve listened to many of your podcasts, some episodes many times. In a couple recent episodes I’ve listened to, you mention that big pharma, gates and the powers that be want to keep us drinking coffee and watching Netflix. I completely understand why Netflix is bad, but can you elaborate on why coffee is bad? Or point me in the direction of relevant information. Thank you for everything you’re doing
Abuelito
Not to unnecessarily prolong this post, but this is where the good docs wisdom shines: I would not be having these problems if I had focused on decentralizing my finances during my health decentralization process. I only saw the transfer of fiat to real estate and assets which did buck inflation (for now) but was ignorant of crypto. If I had put the majority into bitcoin then I COULD hire better doctors now, I COULD fly him to the equator for a long vacation. Ego went too far up in indignation but after processing for a few days I see I was brandishing a half truth.
Rocky Escalante
“Such a simple thing” ray lamontagne
Rocky Escalante
Ok I give ORNL, uncle! lol
Rocky Escalante
check your labs?
Rocky Escalante
Maybe mr.humble himself orl?
Rocky Escalante
indeed
Rocky Escalante
Ben Harper "she's only happy in the Sun" might be worth a DEEP listen
Rocky Escalante
Nothing compares to a 360 degree view
Rocky Escalante
Sometimes I type right through the noise of my neighbors back up alarm going of, sorry
Rocky Escalante
See Jack, it can be true... time for a reread
Rocky Escalante
anyone paying attention knows, I see this Jack as I see Jack. I see Jack as a modern day Sysyphus-cast out by the gods of madician’ tasked with rolling a boulder (all joking aside) to the top of man’s tallest mountain (somewhere in the Himalayas) for what surely must have seemed like forever and ever and ever (let’s hope he looks back in favor) All this just because a brother wanted to spread a little sunshine. Sysphus understood mans laws of physics and knew alittle about energy expenditure variables and math so he planed ahead, taking with him a stick of grass fed butter and a full stein of beer. The up was not something he cared to remmber however once on top that was a different story. A new strangeness, air rarifed, unfiltered, yet, his visual accuity remained intact. Overcome with an astonishment so great, as to create a slight tremble, arisen at the sight, balancing on the very pinnacle of mans endeavor he raised his stein above the clouds and realeased the stone along with any deception the madgishions of his past had placed upon him. He gave himself that moment of “inebtween” to view the beauty of scattered light with its infintesimal bits of energy, omni-directional wonderland from which he picked through what everyone else had missed and sequestered that to his shirt pocket next to his trusty Bomar Brain while uttering the following: maybe Ive been looking at this all wrong maybe the cosmic joke’s on me too? Looking down through this new panorama, at first it appears to be nothing more than a rather large “switchblade fight in a telephone booth” but with the new found powers of his double ffocus it becomes clear, its majestic, he sees it all, he perceives it all, he can feels everyone’s emotions, he can understands everyones perspective, his fears (if any) are gone, he can now relax, his faather is fine, for he now understands what sinatra’s silver tongue meant when he sang “I’ll do it my way” on his way out of the stadium. Now, he must return, trusty ceramic vessel by his side, his legs are weary yet, off he goes to the land below giving a nod to rick rubin along the path of least resistance whistling a little diddy that goes like this “Better down than UP little buttrcup” Laura for your part If it was simple everyone would do it, capeesh? As of this date it is unclear what the stein witnessed above the clouds
Rocky Escalante
Yea, ol' Vlad constantly reminds u s he can still shit through a knothole at ten yards. E Tama, hang loose
Abuelito
No worries brother. If we all took things a little more personally we would have tikkun olam in whatever time it takes an ICBM to turn Davos into a scree field XD
Abuelito
Very fair point but I think he saw that I was frustrated with the lack of communities where this stuff can be discussed and pointed me towards the forum knowing that it's more oriented towards fostering that kind of support. I don't think it's just a sales funnel towards the forum, if he was all about the $ he would just be hammering out needless surgeries instead of going to war with the system. I will join the forum, just broke as hell right now.
Rocky Escalante
Yes I took it personal too, always do
Rocky Escalante
Trust me at first I took it personal too.
cL34rC0mm
Dr. Kruse - Another Forum post that's UNAVAILABLE to view?
Abuelito
I have and I appreciate the suggestion. He only listens to doctors that he visits, if I had the resources I would hire Dr. Kruse, Dr. Cowan, Dr. Guilhane, Dr. Hazan and a handful of others to ream him out in a phone call lol. That would probably work.
Abuelito
Oh I'm sorry I wasn't disagreeing with your assessment of Einstein (spot on), I was piggybacking off it to crack an unspeakable joke about a related topic.
Rocky Escalante
They are both telling the same story but in different language’s fortunately I catch both frequencies. One frequency is respect one is love.
Rocky Escalante
Yes I understand all about sticking points. Case in point my wife when I ask her to listen she replies: who in the would you want to spend a day on the beach with Jack Kruse or Jack Johnson? These are the question that keep me up past my bedtime
Rocky Escalante
Have inquired about Dr. Hazan? I think your POP and her would see eye to eye but, DYOR
Rocky Escalante
Have you translated the equation? Or read Steinmetz papers?
Rocky Escalante
Borrowed?
Abuelito
I have also wondered if Einstein borrowed his ideas, the glove sure fits on the hand of history nicely. For purposes of conversation with the uninitiated I generally assume it's real and actually happened because it ends up being a sticking point for many people. Wait...what were we talking about?
Abuelito
Ouch! Dang I'm sorry to hear that Laura. May it regenerate swiftly and with minimal pain! I really appreciate the reply.
Rocky Escalante
Perhaps Dr. Sabine Hassan?
Rocky Escalante
To This Einsteinian 1 billion photon claim I offer the following: Charles Proteus Steinmetz in his famous nod to all “monumental masons” gave his little known and unrecorded impression of albert einstein while cleaning up his office after someone had clearly trampled through it. “That cheeky bastard! Not only do I have more than enough compelling EVIDENCE showing he plagerized all my work but, I am now in possession of photograghic PROOF that he stole my wife’s favorite pair of open toe sandals!. In an un-Steinmetz like moment of unclarity it is suggested that he embarked upon what would later become know in certain circles as the “Koleidoscopic Negative Entropy Induced by Dancing with the Wrong Partner” theory. At first only J.C.Maxwell got it however once the language translator came along just about everyone can get it. (DUMM WIE> EIN STEIN 2) Now, unless Sky King is prepared to jump out of his white ultra-light to prove anyone wrong, might I suggest a moment of silence for one of the greatest human beings to grace this world: Charles Proteus Steinmetz 1865-1923
Laura Kissmann
Fascinating insight Abuelito. Sorry you are going through this. I believe this vent will resonate with so many of us here and be helpful. I struggle too with trying to save too many and exhausting my energies/boundaries. Broke my tibial plateau recently and succumbed to surgery - now I am getting more serious about my own health. May we learn from your takeoff - wishing your family the best outcome possible and keep living your example and never stop learning. And agreed - thank you Uncle Jack for another deep dive...
Dr. Jack Kruse
If you have an autoimmune condition, Lyme disease, BPD, FM, or PCOS, this thread might help you a lot. It will show you where your failure points are and why your centralized MD is impotent to help you. https://forum.jackkruse.com/threads/lymes-treatment-options.29472/
Abuelito
I've been trying to get my dad to go outside for about a year now. He's gotten progressively paler and more sickly, just staring at blue screens day in and day out. He got a lung cancer diagnosis a few days ago. Never got the kill shots, this is just regular ol mitochondrial colony collapse (or sv40 from my mom?). He spent his life outside hunting, fishing and running a drainage company. Always tan, always immensely durable with this huge capacity for regeneration. His healthy friends are still tan as can be. One still smokes and had COPD 20 years ago. Kept fishing and his lungs are clear. Dad will do nothing now. Just sits and watches what the clownworld algorithms feed him, holding his phone in front of the tv through transition lenses. First a heart attack ten years ago, then apnea, addiction, then hearing loss, weight gain and now this. Textbook heteroplasmy procession and likely still salvageable. He looks older than my grandpa who at 86 is still working full time outdoors trying to save the chestnuts from blight fungus (probably an emf issue). Grandpa spent his career on transatlantic flights for the agency, spent time in antarctica/soviet union (he was stationed at the embassy during the microwave sickness era) , has uv blocking lenses installed and always wears long sleeves, yet can work 10 hours straight digging post holes. He fell 16 feet from a ladder a few months ago, crawled back to his truck and was a-ok. Ungodly low heteroplasmy rate in the family that my dad just won't use to his advantage. My grandpa offered to help pay for his DDW when I sent him the studies. The reaction today when I swung by? "I'm not gonna drink some weird water. you're not a doctor" Followed by my mom after a scoff (also newly pale and with severe asthma thanks to the jab) "maybe I can water my plants with it" CNN grandpa "let's make sure the doctor approves of this" (this Idiocracy-extra of a button pushing doctor who doesn't know why his son has autism but can sure parrot back what the trelogy rep programmed in? Debt and rote memorization of bad science doesn't make you a doctor, it makes you a priest for a useless religion) This escalated to mockery "you think the sun can fix this?" and eventually to screaming "you're a liar!" 100% predictive power over the last four years. That's the root of my social ego, that's my familial pride: I got shit right over and over again about this one domain (geopolitics and its relationship to public health) and my family actually valued it. They didn't want to hear about metastudies, laboriously translated taboo russian works, 2000 year old historians who said too much or leaked 19th century plans of world domination, but they sure liked the predictive power. Curious how simply listening to dissenters gets you blessed with the label of "family prophet" in a world of official lies. Correctly predicting how covid would play out, how the banking cult printing double the money would affect their retirement accounts, what the result of every major psyop would be. All happily accepted and acted upon based on presented evidence...until it came to the fear of that word-made-magic: "cancer" Now the goofy fuck of a doctor struggling to recite Rockefeller mantras through broken english is suddenly holy writ. The people dad rightfully distrusted through covid have become a lifeboat. The son has done his job, to seek the thing that might restore his sickly father. The pale, depressed king sends the young prince to find the elixir that will lift the proverbial curse. I journeyed. The journey transformed me. No fear of death now, just the cherishing of life, of time. In seeking his cure I found my own. I wrested the precious knowledge from the jealous grip of these pseudoscience-pushing billionaires but his hands will not take it from me! Every vector attacked, every rabbit hole excavated, every communications tactic harnessed. I spent years learning, separating the wheat from the propaganda with the overarching goal of helping my dad. Nothing but mockery and dismissal when it comes to that fear of illness. I can't keep pushing energy into these unthinking zombie-people. I just went home and smashed up one of my thrift store chaise lounges (in the sun, barefoot) to drain the negativity. Something has changed. I see my cnn and fox neighbors walking by pale and coughing and I conceal my sneer where there was compassion before. The old homeless guys I talk to at my local stores suddenly seem much more like old friends or even family, because without exception they are still capable of rational individual thought (they spend all day in the sun, coincidentally). They present ideas that are their own, not repackaged snopes propaganda. One guy is a BHI in his 60s and once we got through the racial distrust and he realized us "lesser" whites and american blacks have a common adversary we have become close and he actually gets AM sunrise now. Brothers reunited against the dividers. I am aware that this sounds like the ravings of an insulted narcissist. I'm not, but I'm realizing a healthy ego is a shield to the parts of you that are compelled to care. Time to hold the shield properly and stop pretending that all humans must be saved. It's not my job, not my life and not the black hole into which my energy must pour. I understand the wisdom of the Talmud now: those of strange and unnatural beliefs are not like us, they have chosen to be like cattle and follow: treat them accordingly. It feels like a takeoff: Pattern recognition online. POMC engaged. Opsins mapped to the heart of the sun. Thermal tiles at 10,000K and climbing but the vacuum is cold and I need my CT, let's open the windows baby! Dodging the Perseids (no autopilot), preparing to slingshot around planet bullshit. I'm going home to that third little rock and if you'd like to visit you can cash me outside <3 Sorry to vent Dr. Kruse. There is just no other community I know of with a bunch of people going through exactly this. O'Becker and Ling were the butterflies, you are the tropical storm in that nonlinear relationship and collectively we are the hurricane that will sweep the nonsense away. Thank you for the new deep dive.
Rae Whitten
Fascinating!
