Dr. Jack Kruse
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DECENTRALIZED MEDICINE #15: TURNING YOUR "WHAT" into your WHY.
🕑 Added 2024-09-26 19:30:49 +0000 UTCYou're going to be retooled with knowledge and reschooled with Nature's wisdom today. Share this decentralized wisdom with the world.
Do we need to know our "WHY"?
I think we do.
Without knowing our why I believe the attainment of Optimal will not happen.
I was getting ready for a medical talk earlier this year and I was jotting some things down about how my surgical judgement has changed from the time I left residency to the present and going over my practice patterns for the talk. It dawned on me the practice of medicine is very much like the practice we use in life to become a more imporved version of ourself. Inevitably, practice isn't the thing you do once you're good. It's the thing you do that makes you good. I was surprised about the crowd of people I was asked to speak to. The mayor was in the audience and so was some the state health department officials. I had no idea who i was speaking too. I thought it was going to be mostly patients and PCP's in my new referal base for my new job. When I saw that my audience was quite different than I anticipated I scrapped my "neurosurgery talk plan" on minimally invasive spine surgery and decided to talk about how my "what", neurosurgery, led me into my "why", my real passion.........Quantum biology.
The response I got from yesterday's talk even astounded me. I think I realized something about myself yesterday. When I speak from the heart I connect people with nature. That connection is the key to getting my flock well. This is the basis of becoming a mitochondriac. I realized this week that I help people find their "why" in healthcare via biophysics so their wellness manifests. Do you need some clarity on how to move your "what's", to the key "why's" that will eventually move your decision making process to focus on only the things that matter in your life to keep you well? Then reach out to me and join my flock of mitochondriacs right now.
SO GIVE ME SOME EXAMPLES DOC
"The antagonistic pleiotropy (AP) theory posits that aging occurs because alleles that are detrimental in older organisms are beneficial to growth early in life and thus are maintained in populations.
Although genes of the insulin signaling pathway likely participate in AP, the insulin‐regulated cellular correlates of AP have not been identified.
Answer: young humans before full myelination in brain needs deuterium to complete growth but once myelination is complete then mitochondria need to deuterium deplete to control growth and metabolism pathways into adult life. This is the control system for the insulin signaling systems built into the placenta. The proxy for the system is salinity measures. The more salinity in the system the more UV light can be captured in the system to drive morphogenesis.
As deuterium fractions in tissues rise as we age, salinity measures lower. This means we need more sunlight to offset the risks of aging. This is why those with insulin resistance have high BUN/creat ratios and why they are more apt to have SIADH, HTN.
Sodium transporters brings Vitamin C into the brain for TCA cycle protons recycling to lower the KIE of deuterium in TCA intermediates as we age to control volume changes in the matrix. This is why SIADH is associated with cognitive decline in TBI and aging.
MORE DECENTRALIZED LESSONS?
Na also brings calcium into bone in cases of osteopenia. Low Na = low Ca and Mg = mitochondrial dysfunction. Low salinity in CSF and the body is a feature of all nnEMF exposure in environments.
The higher nnEMF in your environment the lower salinity becomes in blood and CSF and lower salinity = sleep disorders. Most people with high insulin levels due to artificial light exposure also are afflicted with sleep apnea due to deuterium rise cause by the altered Vitamin A signaling. The slide below makes this case.
BUN rises as salinity decreases because deuterium fractions are increasing. Salt from our eccrine sweat glands helps cool our body because it augments skin vasodilation ( like UVA light does).
As man made blue light exposure of skin rises, dopamine creation in the eye and brain drop and our salinity in CSF drops and obesity manifests easier due to deuterium content in the choroid of the eye and the skin and subcutaneous fat mass due to melanopsin.
The TRP receptors of melanopsin are affected negatively by deuteration by altered salinity.
What are TRP receptors?
Transient receptor potential channels, were first discovered in 1969. They are multimodal ion channels that act as sensors of photic, chemically, or physical toxic stimuli. These channels are widely distributed in various tissues and play a variety of roles. Centralized science is still yet to realize how these channels work with light. Blu elight varies with the time of the day and this system measures these changes accurately to tell time at the quantum scale.
It all makes sense when you understand bio-physics of the kinetic isotope effect (KIE) of deuterium in the mammalian system. Centralized MDs have no clue about this work. Most have no clue why PUFA's in fake fats are really bad: they increase proton leakage in mitochondrial matrix and allows more deuterium in matrix than should be there and this raised heteroplasmy rates to cause disease.
SUMMARY
How do we link the lessons I have taught you over the years to light?
CLOCK and BMAL1 are positive regulators of circadian gene expression in humans, and PER and CRY are the negative regulators that operate under day and night cycles.
Blue light and nnEMF liberate Vitamin A and when it is free in the system it sets off a chain of events. None fo them are good for the non visual photo receptors. For examples, it becomes an aldehyde that destroys the small molecule modulators of the mammalian circadian mechanism shown in the picture above. Once the molecular clock goes awry in a tissue with poor light signaling the implications for many neolithic diseases spiral out of control. What are some of the Vitamin A proteins involved in this downward spiral?
They are called retinoic acid receptor-related orphan nuclear receptors or RORs for short. The RORs have several isoforms too called RORα-γ. These proteins are also under the transcriptional control of CLOCK/BMAL1 heterodimers. This is bad news for the circadian control of PER.
SIRT1 regulates the activity of BMAL1 and CLOCK, two circadian transcription factors, which target NAMPT, an enzyme that synthesizes NAD+ in cytochrome 1. And in a curious feed-forward mechanism, CLOCK and BMAL1 enhance SIRT1 expression… genetic deletion of any of these players induces insulin resistance in humans. This is how chronic blue light exposure causes diabetes. Food does not cause it. LIGHT DOES. Food exacerbates the situation only because carbohydrates make 50% less water at CCO compared to fats.
Sunlight is a NATURAL calcium channel blocker that alters the firing rate of voltage-gated channels on cells. SUNLIGHT in the AM increases the amount of PER protein that is made in the cytoplasm to get to a critical concentration where it enters the nucleus. This alters the free radical signal in mitochondria. Recall all free radicals have one unpaired electron and this makes them magnetochemicals that contol timing decisions in the cell. They act as a logic gate to chose the proper metabolic pathway to use.
This is done in a few ways with sunlight. AM sunlight increases PER, and later in the AM UVA light shows up = nitric oxide (NO) release = lowers BP and controls stem cell depots and the blue light in sun balanced by red light also stimulates melanopsin relaxation of the arterioles in our skin as another collateral effect. This one reason why just going outside in the sun and clean air reduces depression and anxiety because sunlight slows breathing and improves oxygenation. When PER is not made by sunlight depression and suicide are more predictible. Indoor living and ALAN lead to depression and suicide because PER is not made by AM sunlight. the picture shows you the effect in the SCN. It is devasting to the signaling in the leptin melanocortin semiconductive pathway. Smash that blue hyperlink now.
Breathing indoors requires us to use suboptimal air which is not moving or mixing with the wind or interacting with the sun so its charge is lowered. This poor oxygen level = pseudohypoxia = poor PER creation in the AM ---> NAD+ drops = higher heteroplasmy = you age faster = more sympathetic activation = more PVN firing = less vagal tone = you get sick quicker indoors. More than 90% of you live inside.
As a result, SIRT 1 lowers with INDOOR living = alters PER cycling in the SCN and every tissue from the cytosol day and night from the nucleus.
Why is this a big deal? When PER one cycle is off so is NAD+ at cytochrome 1 and this causes advanced aging in man due to heteroplasmy because deuterium is let into the mitchondrial matrix where it is not supposed to be!!!
NAD+ is one of the more immediate players in cytochrome 1 that is a huge driver of circadian biology in humans. It is the coenzyme called nicotinamide adenine dinucleotide (NAD+). It participates in a variety of redox reactions in the matrix that help generate DDW. Solar exposure and fasting work with light frequencies to slow ECT flow and this can increase the intracellular NAD/NADH ratio if the light environment is dominated by sunlight. It won't do this with artificial light. It lowers NAD+. This is what sets off a cascade of circadian events that can destroy tissues because they involve epigenetics and the regulation of growth and metabolism of man. LIGHT DOES THIS. NOT FOOD OR FUELS.
SUN + fasting -> PER cycling is controlled by AM sunlight ---> raised NAD+ -> SIRT1 -> BMAL1/CLOCK -> NAMPT -> NAD+ is increased.
You've now been retooled with knowledge to be reschooled with wisdom. Share this decentralized wisdom with the world.
CITES
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5418193/
Comments
Dr. Jack Kruse
What would happen if you gave yourself permission to do something you’ve never done before? There’s only one way to find out, isn't there? If you want a new outcome in your life you must begin by doing something you've never done before beginning right now. Get in the sun and turn off the lights at night to protect the regenerative currents in you. Follow your own passion—not your parents’, not your friends or mentors' — just tap your own instincts. There is no passion to be found playing small—in settling for a life that is less than the one you are capable of living. Learn why light is the most dangerous drug out there. It is not food. It is a story about light 100% of the time. https://www.instagram.com/p/DBr1p-ShjFG/
Abuelito
Sorry I can't answer your question exactly, but I can provide this: 1) Varies. Generally early on you'll need more than later on when your redox is improved. I am 95% sure Uncle Jack said that on a podcast, but I may be mistaken. I like to do 30 minutes before anything else then eat breakfast and immediately come back out to optimize digestion, but that's just what I can get away with personally at the moment. Missing either of those things messes up my day. With presently good redox I feel ok with 10-15 minutes on rushed days. More is better here, because "all the time" is the optimal. The sun changes continually throughout the day in regards to both intensity and spectral ratios. We developed to track that all day every day on unclad flesh and little burst exposures of "am sunrise!" and "midday sunrise!" are just useful constructs to hack the most important signals in a busy modern world. Why accept a B when an A is available? It's your life, your time, your health. Fucking seize it my brother and bathe in the glory of Ra! lol. 2) TINA. Sun is still best with cloud cover. Most of the light comes through and the body evolved with cloudy weather.
Jonathan Binder
What is the minimum effective dose of morning sunlight? What is the best alternative for cloudy days? 🙏🏻☀️
Mary Bourriague
I have sent out to all I know your teachings. I hope for enlightenment and critical thinking to open their eyes to what is really going on. I am 62 so this all is not a stretch to see, but today’s people under age 40 or so are MKUltraed for the most part. Not just sad, very tragic for them and their / our world future.
Mary Bourriague
I have experience with that and I could burn your ears completely off while discussing that topic…. You would listen. Most people just don’t get nor want to hear the backstory of dirty environmental politics…
Dr. Jack Kruse
Great choice. seems like CA needs more of you with all the forest fires they have.
Abuelito
I instinctively bucked at this then searched my noggin for better ones, nada. Motion seconded brother Boris.
Susan
I am having the same issue, no one has approved me for months, Jack can you advise what to do? Thanks, Susan
Mary Bourriague
I knew there was a reason at age 10 while skiing my dad told me to get an outdoor job. So I did and became a CA Registered Professional Forester. I could regularly tell time accurately within 5 minutes by using only the sun’s location. Being outdoors was everything. I promoted to many desk jobs, like many, but the woods were always where the real world could be found. Still is. All foresters detest being indoors. It is unnatural.
Abuelito
I've been giving out two sets of information: 1) black swan mitochondriac stuff for people who oppose tyranny 2) food guru stuff for the people who think tyranny is a good idea. I just gave one of them my ipad and suggested replacing his halogens with leds...for the environment. "Seed oils are good in winter, because fat helps generate heat" >:) I spent a lot of time over the last year trying to help people who really ought to be as cognitively and physically impaired as possible in order to protect the rest of us. Not suggesting that is true of your bio friends whatsoever, but be selective and we can reduce the number of useful idiots available to the bankers/pet governments during the next psyop. Many people are a clear and present danger to the species and centralized science has given us the legal tools to help usher them from the field. We are at war.
D358
My big bio phd friends think I’m nuts but this really makes so much sense. Need to retrain them !! Great info appreciate it 🙏
Julian Frank
Would anyone be able to help me get approved for the forum? I have my name and photo there and everything. Thanks
Boris Leoro
Uncle Jack you are the greatest doctor of all time.
Dr. Jack Kruse
ask her i have no idea what she shared
Gaby
Hi doc. I saw a post shared the other day by Dr. Alexis about autoimmunity in one of your forums. Where can I access this? Ty
James Fambro
Thank you 🙏🏽
cL34rC0mm
Start here on Patreon at less than the cost of a cuppa coffee per month($5USD) or ... Get more premium content and access to webinars + Q&A sessions with much more personal attention, more perks and get your questions answered as a Silver or better a Gold member at: https://kruseatdestin.com/optimal-klub-membership/
Shelly Hilliard
Thank you! I look forward to your new posts and learning how to implement this knowledge into my life - and sharing with others!
James Fambro
How does one become a member of your tribe, Dr. Jack?
Divya Darbari
This article is so brilliant. So grateful for your wisdom and passion to share with the world. Thank you Dr Jack !
Christie
THIS! it dawned on me recently (while out sun gazing at sunrise ) that you are plugging people back into creator /life ...a reunion of sorts...of what our soul /spirit KNOWS at such a primordial level by waking people up and plugging them back into LIGHT /nature . and the BIGGEST part ...its FREE. grateful beyond words for your passion , heart , mind and contribution to humanity . you woke me up in 2019 and changed my life. "When I speak from the heart I connect people with nature. "
